1100 Main St

About:

Situated directly across from the Buffalo Niagara Medical Campus and steps from Allentown, 1100 Main Street is a highly visible, multi-tenant office building with on-site parking in one of Buffalo’s most active commercial corridors. The office building combines a strong Main Street presence with flexible floor plates that suit a range of professional and medical tenants.

Available Space:

• Suite 120: 3,300 Square Feet
• Suite 250: 12,460 Square Feet

Property Specs

• Building size: ±38,682 SF across multiple levels.
• Site size: ±0.8-acre parcel in the Bryant neighborhood of Buffalo.
• Parking: Approx. 40 on-site surface spaces directly adjacent to the building.
• Year built: Circa 1920, with opportunities to highlight historic architectural character.

Ideal Use:

• Medical, professional office, or service-oriented users seeking proximity to the Medical Campus.

Building Highlights

• Prominent Main Street frontage with strong signage and branding opportunities.
• Flexible floor plates well-suited to exam rooms, open office, or hybrid layouts.​
• Walkable access to the Buffalo Niagara Medical Campus, Allentown, and nearby restaurants and services.
• Close to Metro Rail, major bus routes, and key city thoroughfares, providing easy access for staff and visitors.
• Potential for façade enhancements that celebrate the building’s early 20th-century history and original auto-dealership roots.